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DeCS
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Descriptor English:
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Protein S Deficiency
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Descriptor Spanish:
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Deficiencia de Proteína S
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Descriptor Portuguese:
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Deficiência de Proteína S
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Synonyms English:
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Deficiencies, Protein S
Deficiency, Protein S
Hereditary Thrombophilia Due To Protein S Deficiency
Protein S Deficiencies
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Tree Number:
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C15.378.100.800
C15.378.147.890
C15.378.925.800
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Definition English:
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An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523) |
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History Note English:
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95
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Allowable Qualifiers English:
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Record Number:
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32063
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Unique Identifier:
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D018455
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Occurrence in VHL:
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Similar:
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DeCS
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